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Karin Russian Selected Research

BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)

6/2010Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant.
8/20099-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.

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Karin Russian Research Topics

Disease

2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2010 - 08/2009
1Neoplasms (Cancer)
08/2009

Drug/Important Bio-Agent (IBA)

1Phosphotransferases (Kinase)IBA
06/2010
1AP 24163IBA
08/2009

Therapy/Procedure

1Oral Administration
08/2009
1Therapeutics
08/2009